Saturday, December 24, 2016

hancox

Hancox: a house and a family

by Charlotte Moore

Charlotte Moore was widely known in autism circles back in the 00s, when she wrote a regular Guardian column called Mind the Gap on her family life and bringing up two boys with autism and one without. This led to a memoir George and Sam about her autistic sons, which I also read and enjoyed, so I took notice when in 2010 she published another book about her family, this time focusing on the house she lives in and the Victorian ancestors from whom she inherited it.

I picked up a copy from Oxfam at some point, but somehow it never got to the top of my wobbly reading pile. Until we started renovating our own crumbling old house, and I wrote a blog entry about it. The clever “link within” widget that cross references my entries dug up an earlier mention of Moore’s book, which I took as a hint and actually read it.

The house as such takes up a slightly smaller role than I might have expected, but it is a suitable foundation to construct a family history narrative on, and as it happens it is also an archive that appears to hold immense treasures of written materials from love letters to furniture bills. It appears to be a family trait that no piece of paper with written information was ever thrown away. This, like many other details, made me think that the autism genes in her family may be similar to those in mine.

At the centre of the family story (although slightly aloof as he had a very busy professional life) stands the physician Sir Norman Moore (1847-1922), only child of a single mother, who twice married women from the vast Leigh Smith clan (descendants of the abolitionist William Smith, MP), which provides most of the surrounding cast, including famous Victorians such as the Arctic explorer Ben Leigh Smith, the women’s rights pioneer and co-founder of Girton College Cambridge Barbara Leigh Smith Bodichon, and, more remotely, Florence Nightingale.

Most members of the extended family are unusual for their time and social environment. We find a lifelong lesbian couple benefiting from Queen Victoria’s disbelief, a man with three parallel families in different social strata, allegedly trying to undermine the class system, several very early feminists, and lots of fraternising with the servants and volunteer work to help the poor. Although at the end of the day, when it comes to serious business like marriage, there is just as much disapproval of aspiring in-laws as in more conventional circles.

What surprised me is that in the early 20th century much of the family’s daring to be different funnels into converting to Catholicism, which strikes me as slightly at odds with the social radicalism of the earlier times. And as the “Great War” strikes, the family is at one with the zeitgeist, and nobody questions the sense of the great slaughter in the trenches, although the family lost a son in the first year of the war.

In any case, the whole, extremely well documented family history and associated social history makes for an interesting read, all the more so if you reflect how the various extents of eccentricity on display here may have funneled into the author’s autistic offspring.

As I have shown the book cover before and it is sure to resurface among the cross references below, here's a portrait of Sir Norman Moore, from Wikipedia.

Wednesday, December 21, 2016

open archives 2015

my features in Current Biology become freely accessible one year after publication. So, by now, all features published in 2015 or earlier are in the open archives. Here are some of the highlights of 2015:

Listen out for life (astrobiology and SETI)

Can we change our predatory ways? (Homo sapiens as a weird kind of apex predator)

How life shaped Earth (my contribution to a special issue on the history of life on Earth)

How to protect the last free-living humans (on uncontacted tribes)

Can we avert marine mass extinctions? (given our track record wiping out terrestrial megafauna?)

Assessing humanity's global impact (and the case for the Anthropocene).

PS: New Year's resolution - from January onwards, I will highlight one of the old articles from the open archives on the Mondays between those when a new feature appears.

Tuesday, December 20, 2016

cancer stem cells

My review of the book

Cancer Stem Cells: Philosophy and Therapies

appears in issue 10 (December) of Chemistry & Industry, on page 39, (restricted access)

under the somewhat misleading title:

Stem cells for cancer therapy?

Here's the snippet from the review explaining what it's really about:

"What if cancers also relied on stem cells for their growth and spread? If they did, it might be pointless to try to kill the largest possible number of tumour cells. If just one or two cancer stem cells got away, they would start a new tumour, which might explain the frequently observed relapses after seemingly successful treatments. Instead, to cure a patient from cancer, it might be necessary and sufficient to kill all its stem cells."

Monday, December 19, 2016

no miracles needed

The end of year period is always a good one to reflect on our place in the Universe and where we all came from, ie to write another feature on an astrobiology theme. This year it's about recent insights into possible mechanisms relevant for the origin and early evolution of life up to and including the RNA world.

The feature is out now:

How life can arise from chemistry

Current Biology Volume 26, Issue 24, pR1247–R1249, 19 December 2016

FREE access to full text and PDF download


Rapid progress in investigations into the origin of life is adding to our understanding of how the emergence of evolving systems from prebiotic chemistry may have happened – without the need for magic. (Photo: Rama, Wikimedia Commons.)

Saturday, December 10, 2016

k315

this term's addition to my nascent flute repertoire is Mozart's stray Andante, K315. The modest speed means that I can actually play along with the CD I have, drown out Aurèle Nicolet and pretend I'm performing with an orchestra, which is great fun.

Next up, some "American" period Dvořák ...

PS (2017): When I wrote this entry, I wasn't aware that Aurèle Nicolet had died earlier that year (30.1.2016) - his passing seems to have been ignored by the UK media. See this appreciation from the Berlin Philharmonic.

Thursday, December 08, 2016

catching up

oooops, I seem to have neglected the round-ups of my publications in German, so here goes from July through to December 2016:

Neurochemie: Vogelspinne zeigt neue Schmerz-Wege
Chemie in unserer Zeit Volume 50, Issue 4, page 159
abstract and restricted access to full text

Netzwerk Leben: Calcium rundum vernetzt
Chemie in unserer Zeit Volume 50, Issue 4, pages 224-225, August 2016
abstract and restricted access to full text

Ökosystem: Eine globale Nährstoffpumpe
Nachrichten aus der Chemie Volume 64, Issue 7/8, pages 738-740
abstract and restricted access to full text

Ausgeforscht: Bier - neu definiert
Nachrichten aus der Chemie Volume 64, Issue 7/8, pages 819
restricted access to full text and PDF download

Ausgeforscht: Küche gegen Labor
Nachrichten aus der Chemie Volume 64, Issue 9, page 935
restricted access to full text and PDF download

Netzwerk Leben: Ein Thermometer, das auch wehtun kann
Chemie in unserer Zeit Volume 50, Issue 5, pages 352–353, October 2016
abstract and restricted access to full text

Medizinische Chemie: Schmerzbehandlung ohne Suchtgefahr
Nachrichten aus der Chemie Volume 64, Issue 10, pages 952-954
abstract and restricted access to full text

Forensik: Fälschliche genetische Fingerabdrucke
Spektrum der Wissenschaft Nr 10, pages 29-30

Wie entstanden und funktionierten die ersten Nucleinsäuren?
Chemie in unserer Zeit Volume 50, Issue 6, page 370
abstract and restricted access to full text

Netzwerk Leben: Erkennt die Signale
Chemie in unserer Zeit Volume 50, Issue 6, pages 420-421, Dez 2016
abstract and restricted access to full text

Biowissenschaften: Insekten als Indikatoren
Nachrichten aus der Chemie Volume 64, Issue 12, pages 610-612
abstract and restricted access to full text

Ausgeforscht: Der Duft der alten Bücher
Nachrichten aus der Chemie Volume 64, Issue 12, page 1235

Also, congratulations to Chemie in unserer Zeit for completing its 50th year, here is how it all began, back in 1967:

Monday, December 05, 2016

evolution of cities

towns and cities seem to be growing "naturally" wherever humans decide to settle and start to trade. Intriguingly, some key parameters of their growth appear to have remained constant from antiquity to this day, suggesting that neither technology nor political organisation has had much of a say over the human tendency to aggregate. Now, however, as the majority of people already live in towns and cities and billions more are to follow, we can't allow settlements to grow on their own. Good and sustainable planning is required to make sure that the dramatic urbanisation of our species doesn't lead to large scale disaster.

I've explored these issues in my latest feature which is out now in Current Biology:

The urbanisation of our species

Current Biology Volume 26, Issue 23, pR1205–R1208, 5 December 2016

FREE access to full text and PDF download



The mathematical equations relating the growth of population density of a city to its population size apply to medieval cities just as well as to modern ones. The photo shows a side road in the historic part of Mainz, Germany (own photo).

Monday, November 21, 2016

forest biodiversity

the ongoing deforestation of our planet is a major crisis, but it's not only about the loss of forest area. The biodiversity is important and endangered too, and recent analyses suggest it gets too little attention. Hence my latest feature:

How can we save forest biodiversity?

Current Biology Volume 26, Issue 22, 21 November 2016, Pages R1167–R1170

Restricted access to full text and PDF download
(will become open access one year after publication)

Magic link for free access
(first seven weeks only)

Forests with a rich mixture of species not only look more interesting, they are also more productive and can thus better protect us from climate change. (Image: Deborah Taylor.)

Sunday, November 13, 2016

the end of the world

it is the end of the world as we know it, and it may lead to the end of the world full stop. Children born this year have a theoretical life expectancy that would take them close to next century, but I'm now fairly sure that our civilisation will not survive that long. Rather than adding to the general tsunami of comment, I'll just compile a few links here, both to my own earlier articles and to recent opinion pieces that I found helpful. (last updated: 25.11.2016 - updates will appear at the top of the lists)

Mon 9.1.2017 my feature on the trumpocalypse and the post-truth world is out now.

George Monbiot: The 13 impossible crises that humanity now faces

George Monbiot: Neoliberalism: the deep story that lies beneath Donald Trump’s triumph

"Hitler's only kidding about the antisemitism" New York Times, 1922

Naomi Klein: It was the Democrats' embrace of neoliberalism that won it for Trump

Gloria Steinem: After the election of Donald Trump, we will not mourn. We will organize

Simpsons writer says President Trump episode was 'warning to US'

My features on related topics:

Will our civilisation survive this century?
Current Biology, Volume 23, Issue 23, R1017-R1020, 2 December 2013

Angry voters may turn back the clock
Current Biology Volume 26, Issue 15, pR689–R692, 8 August 2016

Cover of the first issue of Der Spiegel after the election.

Friday, November 11, 2016

lighting the future

Edison-style incandescent lamps have disappeared from the shops. The energy-saving compact lamps that replaced them are also likely to go, and are already being replaced by even more energy-efficient LED lamps. But is this the best solution, the ultimate light bulb? Will they last as long as Edison's bright idea? In my latest feature for Chemistry & Industry magazine I looked into new developments in lighting technology:

What a bright idea

Chemistry & Industry Volume 80, Issue 9, pp 22-25, DOI: 10.1002/cind.809_8.x

Free access to full text (HTML) via SCI.

Restricted access to full text and PDF download via Wiley Online Library.

an installation of lights and chemical glassware in the windows of the Wellcome Collection, London (own photo).

In the same issue on page 38-39, there is my review of the book "Bananaworld" by Jeffrey Bub (premium content).

Tuesday, November 08, 2016

Australian genomes

After rapidly developing the second and third generation sequencing methods that make it feasible and indeed affordable to sequence many human genomes, research has been slow to turn to address human genetic diversity (most of which is in Africa, not between the arbitrarily defined "races") and the migrations in which our ancestors spread out around the globe. Even though extinct relatives including Neanderthal and Denisovan have had their genomes published years ago, it's only now that Australia and Papua New Guinea are receiving adequate attention. The genomes of their indigenous populations cast a unique and revealing spotlight on the history of our species.

Read all about it in my latest feature:

Out of Africa, into Australia
Current Biology Volume 26, Issue 21, 7 November 2016, Pages R1119–R1121

FREE access to full text and PDF download


Since modern humans expanded into the Australian continent some 40,000 years ago, they developed a rich landscape of cultural and linguistic diversity — until the arrival of the colonialists who failed to appreciate their ancient civilisation. (Photo: © Wayne Quilliam Photography/Yothu Yindu Foundation.)

Sunday, November 06, 2016

this old house

Now that our house has become a bit quieter, we’re doing some long-overdue repairs, and while uncovering the bricks and floorboards we’re also exploring some of its history, if only so we know who to blame if it falls down on us. Seriously though, if anybody happens to know any further details, please let me know.

The story starts in 1883, when the third batch of plots of our neighbourhood was sold to individuals for investment or development – the unique mix of many different styles still on display today is the result of this. Together with William Street, and the short stretch of Marston Road between these, this is the oldest part of New Marston. The oldest surviving buildings date to the 1880s.

On the 12th of February 1883, the Oxford Industrial and Provident Land and Building Society Ltd. sold the plot of land to Mr Harry Charles Poulter, of 59 George Street, Oxford, College Servant, for the sum of 12 pounds 10 shillings. The land is described as Lot 25, “a plot of freehold land in the parish of Marston, in the county of Oxford”. It is one of the 59 lots comprising the “No. 8 Estate”, which covers the last third of the area, most distant from the Marston Road (then the Main Road), but closest to the city. In our section, the plots are 22 foot wide, in the middle section they are the most generous at 24, and towards the Marston Road under 20. Our block is described as “coloured in blue”, but the blue has faded quite a bit in 130 years. Estates No. 6 and 7 are coloured yellow and pink, respectively. Come to think of it, it’s real life Monopoly, with blocks of properties tied together by colour.

On the same day, the plot situated back to back with ours, facing the back lane that is now Edgeway Road, which was then Lot 9 in the same batch, was sold to Frank Poulter, the younger brother of Harry Charles. Both can be found in Ancestry. Harry Charles was born in George Street Oxford, in 1850, where he still lived at the time of buying the land. He went on to marry Ellen and they had six children born between 1888 and 1900. His brother Frank was born in 1862. Their parents were Henry Poulter and Mary Ann Eaton.

On the 17th of April 1906, Mr Harry Charles Poulter (now residing at 26 Buckingham Street, Oxford) sold the plot to Miss Sarah Austin of 93 Southfield Road, Oxford for £ 19,-. The document we have on this transaction is dated 27.10.1913, obviously prepared to facilitate the onward sale now including a house.

On a map of the area dated 1910 the house is clearly shown, as well as 123 Edgeway Road, but no other houses towards the far ends of the roads:

On the 20th of November 1913, Miss Sarah Austin sold the plot to Mrs. Emma Andrews, complete with „the messuage or tenement erected thereon and now in the occupation of Thomas Austin“, along with the back-to-back plot in Edgeway Road (Lot 9), combined purchase price £ 160. In Kelly’s Directory of 1913 „Austin, Thomas, builder“ is listed as a New Marston resident without an indication of his specific address.

On 21.3.1938,Emma Andrews sold Lot 9, today known as 117 Edgeway Road, to Sidney Cooke and Harold Lisemore. On July 28th, 1940, Emma Andrews, then residing at 113 Sugworth Lane, Radley, Berkshire, died leaving her sister, Mrs. Rose Annie Timms, as well as Doris Silvester to execute her testament.

On August 9th, 1943, Rose Annie Timms, widow of Frederick Timms, 31 Culham, sold the house to Emily Gladys Maud Dore, 80 Great Clarendon Street, “spinster”, for £ 100.

On July 8th 1961, Emily Gladys Maud Dore, then resident at the house, died intestate. Her father, retired master carpenter Victor Henry Dore, was the only relative entitled to her estate and thus inherited the house, which in May 1964 he sold to the company Pristacott Developments (Towersey) Ltd., 57 High Street, Oxford, for £ 1400.

On July 27th 1964, Pristacott (now based at 43 New Inn Hall Street) obtained planning permission for an extension to create a bathroom and change the baywindow at the front. Of February 9th 1965, Pristacott obtains a more wide-ranging planning permission also including the garage: “Extension to form bathroom, porch and garage for private car”.

At least since the mid 1980s, and until his death in April 1993, the author, tutor and editor John Blackwood lived in the house. He used the garage to run a small publishing company, Charon Press, with the photographer David Collett of William Street, where they published their own books including “Oxford Gargoyles and Grotesques” (1986) and similar ones on Windsor’s gargoyles and “London’s immortals”. Being located in Ferry Road, the publishing house was named after the ferryman to the underworld of Greek mythology, who came early to pick up John Blackwood.

Open questions:

We're still unsure as to what the kitchen/bathroom arrangements may have been like before our current bathroom was built in 1964. The room plan may have been like this one. In contrast to that plan, the backside window of our dining room (kitchen in the old plan) appears to have been converted from a door, and right next to it the outside door of the kitchen(scullery) appears to be original (judging by the very Victorian brick arc at the top), but does that mean there was no internal door between dining room and kitchen?