plastic electrodes plugged into brain

Among this week's Advanced Materials Early View there is a paper on using polymer electrodes to establish permanent electronic contact with living brain cells. The authors claim the quality of neuronal recording with their device is better than with conventional metal electrodes. This sounds very promising to me, both in terms of restoring function to people with nerve damage, and also with regard to sci-fi style brain-machine interfaces. As I've said before, the boundaries between electronic and biological systems are disappearing.

Reference:

Interfacing Conducting Polymer Nanotubes with the Central Nervous System: Chronic Neural Recording using Poly(3,4-ethylenedioxythiophene) Nanotubes
Mohammad Reza Abidian, Kip A. Ludwig, Timothy C. Marzullo, David C. Martin, Daryl R. Kipke
Published Online: Jul 29 2009 9:30AM
DOI: 10.1002/adma.200900887

ocean mixing by jellyfish

I love the ocean-mixing paper in today's issue of Nature (and on the cover). Essentially, researchers believe that turbulence created by fish swimming around doesn't do much for ocean mixing (as it's limited to small scale and gets lost in friction), but the authors find evidence for surprisingly large mixing effects simply from the layers of water that a swimming organism drags along (details depending on its shape, and the viscosity of the water).

This mechanism was first considered in 1953 by the grandson of Charles Darwin, who is confusingly also called Charles Darwin (the authors of the Nature paper never bother to tell us that it is not the Darwin they are talking about!).

Understanding ocean mixing is especially important today in the context of climate change, as the oceans have a much higher heat capacity than the atmosphere. They also store more carbon, and are instrumental in natural processes of carbon sequestration (e.g. calcite sediments).

Im just a bit worried what creationists will make of this story. Soon they will be telling us that the big bearded guy put jellyfish in the oceans to ensure proper mixing ...

ref:

Kakani Katija & John O. Dabiri
A viscosity-enhanced mechanism for biogenic ocean mixing
Nature 460, 624-626 (30 July 2009) | doi:10.1038/nature08207

News & Views by William Dewar on page 581

aptamers guide chemotherapy

Aptamers are single-stranded DNA (or RNA) molecules selected from millions of possible sequences for their aptitude to bind a specific target. Developed originally as an alternative to antibodies for biotech applications, they have recently found application in sensors and in the treatment of age-related macular degeneration.

Researchers have now very cleverly combined liposome packaging and aptamer targeting to direct chemotherapy (e.g. cisplatin) to tumour cells (e.g. breast cancer). All the known advantages of DNA aptamers apply (non immunogenic, easier to produce and handle than antibodies), and on top of that one gets the chance to call back the attack if it goes wrong, by injecting antisense DNA.

Read my story in Chemistry World (free access to all).

Earlier pieces about aptamers include Chemical Origami (Chem. World 2006, restricted), as well as a chapter in The birds, the bees and the platypuses. I've also reviewed a book about aptamers, review should appear soon.

climate change special

Today's issue of Current Biology is a special issue on "Biology and Climate Change", and very exceptionally I have two pieces back to back in the magazine section at the front.

First there is a news feature on climate change policies and debates in the US, UK, China, and Germany ahead of the climate change summit in Copenhagen:

Climate crunch year
As countries around the world prepare for the crucial climate change conference in December, China tries to boost its green investment, Germany debates the pros and cons of carbon sequestration, the US debate a groundbreaking energy bill, and the UK counts the cost of mitigating climate change in the developing world.
Current Biology, Volume 19, Issue 14, R537-R539, 28 July 2009
PDF file (restricted access)

The second is about an Earthwatch industry partnership to investigate how mangroves in Kenya can help mitigate the effects of climate change:

At the frontline
Mangroves are at the frontline in the fight against the consequences of climate change.
Current Biology, Volume 19, Issue 14, R539-R540, 28 July 2009
PDF file (restricted access)

early music and art

I managed to miss the story of the world's oldest flute when I was travelling in June, but found it in the August issue of Spektrum der Wissenschaft. I'm intrigued to learn that the earliest instrument was found just a few feet away from the world's oldest sculpture, in the Hohle Fels cave in south west Germany. Both date from around 35,000 years ago, i.e. around the time when Neanderthals disappeared from Europe.

So it all fits together, our ancestors had visual arts and music and all that, while Neanderthals got bored to death ...

PS original paper on the earliest flute is in Nature AOP

the platypus has landed

... at last a jpg file with the cover of the German edition of "The birds, the bees and the platypuses":



I much prefer this cover design to the one of the English ed., hope it will help the sales accordingly.

The book is available to pre-order at amazon.de

the magic circle

Review of

The mercurial emperor – the magic circle of Rudolf II in renaissance Prague

by Peter Marshall

Pimlico Paperback 2007

Imagine the most powerful political leader in the world decides he’s not interested in politics and wars and all that and prefers to dedicate most of his time to collecting art and dabbling in science. Amazingly, it really happened: the leader in question was the Habsburg emperor Rudolf II, who presided over the Holy Roman Empire in the twilight years before central Europe drowned in the Thirty Years War.

In his very readable biography of the ruler who couldn’t be bothered to rule, Peter Marshall follows the interests of his subject by dedicating only a little bit of space to the politics, and focusing on the art and the science instead. To get the politics out of the way first, many have slated Rudolf as a hopeless leader, but Marshall tends to support the view that his inaction and openness for divergent opinions (especially on religion, where he refused to support hardline Catholicism) quite possibly delayed the inescapable disaster by several decades.

Rudolf’s credentials are much clearer in art and in science. His support for the most exciting astronomers of the day brought together the last and greatest naked-eye observer of the heavens, Tycho Brahe, and the best theoretician of the time, Johannes Kepler. Without Rudolf’s patronage, the movement of the planets (Kepler’s laws) might have remained unsolved for much longer.

Astronomers of the day still very much believed in astrology, or at least used it as a welcome source of income, so we’re looking at an important junction between the medieval world views we now call superstition and the emerging modern science. Thus there are also alchimists and magi like the Briton John Dee populating the pages of this book.

In art, Rudolf supported many great artists, including Arcimboldo, who famously portrayed the emperor as a jigsaw made of vegetables. Marshall says that Rudolf often left important political figures waiting for an appointment, as he preferred to spend his time in the workshops of his artists, discussing their current work.



Of equal importance, though, was his unprecedented activity as a collector. He sent expert buyers including Jacopo Strada and his son Octavio to Italy, to buy art of what we now call the late Renaissance and bring it to Prague, the city which owes the time of its greatest glory to him.

With chapters dedicated to subject areas (magic, art, old astronomy, new astronomy) and the key figures representing them, Marshall’s book is a very accessible read. Minor moans from my part include the fact that the Strada family have not been given a whole chapter as they would have deserved (I have a vested interest here, but I think it’s fair to say that they are at least as important for Rudolf’s circle as the visitor John Dee). I would have also wished the author to be more aware of points where the textbook history may be wrong: He uncritically refers to “Juana la loca” (Rudolf’s great grand-mother in two lineages) as having been mad, and to a strained bladder as the cause of Tycho’s death. In both cases, I would rather take side with the alternative views explained here and here, respectively.

The failure to acknowledge the possibility of Tycho’s murder is especially unfortunate as Marshall reveals further links between Tycho and Shakespeare’s Hamlet: The astronomer, whose research centre at Uraniborg was within eyesight of Hamlet’s Elsinore, had cousins named Rosenkrantz and Guildenstierne. Which rather fits in nicely with the murder case that Peter Andersen makes and that Shakespeare may have known about. As the bard said, there are more things in heaven and on earth …

platypuses reviewed

There is a new review (in German) of my book The birds, the bees, and the platypuses, in Treffpunkt Buch Plus, a shared review supplement that appears with the entire family of "in unserer Zeit" magazine, i.e. Chemie in unserer Zeit, Biologie iuZ, Physik iuZ, etc. While each of the magazines has a very modest print run, I reckon the sum total should be quite reasonable, somewhere between Spektrum der Wissenschaft and New Scientist. The review appers on page IV.

Talking about platypuses, the German version of the book, Der Kuss des Schnabeltiers, is on track for publication in September. We have a lovely cover design which I'll put online as soon as I get a jpg file.

guardian technology & the dead tail of blogging

Recently, I've been looking through a pile of Guardian technology sections which I had piled up for a rainy day, and found a comment by technology editor Charles Arthur (Blogging's long tail is dying), where he explains how he tracks blog entries that comment on content of his technology section. So I reckon he must find this -- hi Charles, *wave*.

Anyhow, to Charles's point about blogging, his conclusion is based on two observations: 1) the reported finding that 95 % of blogs out there haven't been updated for 120 days, so are presumed dead. I don't find that terribly surprising, as there are lots of people who try opening a blog, post two entries with their favourite song lyrics, and find it's not for them, leaving the ruin standing for eternity. In MySpace alone one finds thousands of ghost blogs like this.

Observation no. 2) is that the comment tracking device that Charles set up is giving fewer hits than it used to (and being the editor of the section, he hopes it hasn't become less inspiring over the years). So I'll make a point of regularly commenting on the section to buck this trend :)

At least where I'm standing, which is probably somewhere in the middle of the long tail of blogging, I still feel that blogging is alive.

PS: I forgot to mention that I'm now on twitter:

http://twitter.com/michaelgrr

Copenhagen conference reframed

As I mentioned earlier, I learned lots of interesting things at the Copenhagen conference on Framing Research.

Some of it I reframed as a news feature for Current Biology, which appeared last Tuesday and is available here (restricted access, but email me if you want a copy).

Another item published while I was away is my review of:

A short guide to the human genome,
by Stewart Scherer

This is in Chemistry & Industry, issue 13, 13.7.2009, page 30

Snippet:

In his “short guide”, Stuart Scherer has addressed around 80 such questions, using the available database tools and the published literature to give today’s best estimates, pinning the genome and its proteins down as precisely as possible. Regarding the number of genes in our genome, his answers range from 18,357 to 25,685. Each of these “genome FAQs” is addressed in a very short chapter of just one to four pages, often presenting the answer in the form of a table or graph, together with an explanation of how the results were obtained and what factors still limit their precision.

in praise of TGVs

It really only struck me when I was back in Oxford, Friday afternoon, and realised I had been in Avignon, Provence, the very same morning. Without using a plane. It struck me that these days the TGV (Train Grande Vitesse, or High Speed Train) only takes 4 hours and a bit from the top to the toe of France, i.e. from Lille to Avignon. On the way down it took us 4 hours and 13 minutes. And you never even notice you're moving very fast. And the train arrived precisely on time.

A quick comparison with the UK: the distance corresponds to that from Brighton (on the south coast) to Inverness (on the shores of Loch Ness), and the quickest train connection I can find right now takes 9 hours 49 minutes. which means that most people would take the plane to go up to scotland.

Plus, the new generation TGV trains, some of them double deckers, offer you an amount of space that you would only get in first class carriages in the UK. At one of the stations I spotted a magazine for (UK) railway enthusiasts with the cover page reading: "High speed trains: what we can learn from Europe". Well, ahem, short answer: everything.

The UK has only one high speed line, that is the bit that connects London St. Pancras to the Euro Tunnel, which opened a couple of years ago (before that, the fast Eurostar trains crept very slowly into Waterloo station). Seeing that the Paris to Lyon TGV line opened in 1981, we're about a quarter of a century behind.

Meanwhile, the UK government keeps subsidising the expansion of airports, undermining its own climate targets, as George Monbiot keeps reminding us.

PS couple of pix to throw in, this is the main hall of the TGV station at Avignon:




... and this is what the sunrise over Provence looks like when you move at more than 200 km/h:




PS I've now uploaded a few more photos to a dedicated MySpace album.

olives and lemons

I'm back from a very quick TGV visit to my relatives in Provence, have uploaded a few pictures to my VIEW profile, mainly impressions from Avignon, where the festival was in full swing and theatre was spilling over into the streets to an extent that made it really difficult to work out where the theatrical ended and real life began. Now was that a real street sweeper with the rubbish trolley over there, or an actor wheeling a prop around?




olives at Nyons, not far from the world centre for olive cultivation.



Near the Pont du Gard, an olive tree which looks as if it might be nearly as old as the famous aquaeduct

More impressions to follow ...